Megan Fox has brachydactyly type D: an inborn (clubbed) thumb condition.
After Megan Fox’s clubbed thumb became an internet hit in 2009, one could argue that she is likely the most well-known person in the world who has brachydactyly type-D.
These are the TOP 10 facts about brachydactyly type-D (BDD):
• 1 – BDD is characterised by the anatomic characteristics where the last bone of one or both thumbs is short and round, featured with an accompanying short and wide nail bed. There are various degrees of thumb shortening, either unilaterally or bilaterally. It has been noted that the base of the distal phalanx is broader than the surface of the proximal phalanx to which it articulates, and that the distal end of the bone often shows some hyperplasia. Other investigations confirmed that the short distal phalanx of the thumb results from early closure of its epiphyses.
• 2 – BDD was first described as an anomaly in 1928 by O. Thomsen (O. Thomsen: Hereditary growth anomaly of the thumb. In: Hereditas. Band 10, 1928. S. 261–273.).
• 3 – BDD is a genetic trait associated with gene HOXD13, genomic locus 2q31-q32; HOXD13, the most 5′ gene of the HOXD cluster, encodes a homeodomain transcription factor with important functions in limb patterning and growth.
• 4 – BDD is a minor but common affliction (just a cosmetic defect) that can be found in 1 up to 40 out of every 1,000 people (= prevalence ranging from 0.1% up to 4.0%).
• 5 – BDD varies among populations around the world; according ‘The World of Clubbed Thumbs’ the statistics are: 0.1% of blacks, 0.4% of whites, 1.6% of Jews, 3% of Arabs, and in Japanese possibly up to 4.0%.
• 6 – BDD is sometimes a familial trait, but it appears slightly less common among males due to a reduced penetration (about 62%).
• 7 – BDD is often refered to with various synonyms such as: clubbed thumbs, stub thumbs, stubby thumbs, toe thumbs, hammer thumbs, Dutch thumbs, or a potter’s thumb.
• 8 – BDD was also coined (misleadingly) by fortune-tellers as a murderer’s thumb.
• 9 – BDD is not associated with other abnormal physical characteristics; however, distal phalanges of other digits may also be broad and short. Great toes may be similarly affected.
• 10 – BDD is seen in a considerable list of celebrities, including the actresses: Megan Fox (US actress/model), Malin Akerman (Swedish-Canadian actress/model), Sanaa Lathan (US actress), Leighton Meester (US actress & singer), Vittoria Puccini (Italian actress), Ashley Tesoro (US actress, model & singer), and Anna Walton (UK actress).